Indometacin - Wikipedia
If the pH gradient throughout a cell membrane is excessive, a lot of the indometacin molecules will likely be trapped in a single facet of the membrane with larger pH. This phenomenon is named "ion trapping". The phenomenon of ion trapping is particularly outstanding in the stomach as pH on the stomach mucosa layer is extraordinarily acidic, while the parietal cells are extra alkaline. Subsequently, indometacin are trapped inside the parietal cells in ionized kind, damaging the stomach cells, inflicting stomach irritation. This stomach irritation can scale back if the stomach acid pH is lowered. Indometacin's function in treating sure complications is exclusive compared to different NSAIDs. In addition to the class impact of COX inhibition, there may be evidence that indometacin has the power to reduce cerebral blood circulation not only by modulation of nitric oxide pathways but also via intracranial precapillary vasoconstriction. Indometacin property of decreasing cerebral blood circulation is beneficial in treating raised intracranial pressure. This reduction in cerebral strain could also be answerable for the remarkable efficacy in a gaggle of headaches that's known as "indometacin-responsive complications", akin to idiopathic stabbing headache, chronic paroxysmal hemicranial, and hydroxychloroquine 200mg exertional complications.
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